PERQUE Joint Guard effective formula is built on over 20 years of clinical research successes. Only PERQUE Joint Guard uses the active, fully soluble forms of glucosamine KCl, glucosamine sulfate, and chondroitin sulfate, plus the collagen-building flavanols (soluble OPCs) and molybdenum that are in no other product. Each of the active agents in PERQUE Joint Guard is shown in research to help people with sports injuries and Osteoarthritis move pain free and with greater joint flexibility. By itself each nutrient is effective, but together they synergistically build and restore function at the cellular level.* Glucosamines are building blocks of glycosaminoglycans (GAG) and proteoglycans (PG). This makes up the shock absorber, waterbinding structure of cartilage. Sulfate activates its therapeutic effect. Unlike NSAIDS, which block proteoglycans synthesis, glucosamine and its sulfate address the causes of OA. This halts and reverses cartilage degeneration and supplies the biochemical tools to rebuild damaged cartilage as people feel better.

Recent work reveals the synergistic benefits of the highly active glucosamine sulfate (GS) and glucosamine KCL, combined only in PERQUE Joint Guard. Increased absorption and delivery of the active nutrients to cells means rapid pain relief and faster gain of flexibility.* Soluble Chondroitin sulfate (CS), another joint-supportive, repair molecule, works synergistically with glucosaminoglycans to rebuild cartilage. It has repair-promoting, anti-inflammatory properties, eases pain, helps heal wounds, and has been shown to be protective against heart disease. In studies on the anti-inflammatory effects of CS, patients moved joints more freely and without pain or the complications of NSAIDS.1*

• Comprehensive joint health formula. Restores and renews joint tissue within weeks rather than many months.*
• Enhances and maintains optimum joint tissue health while improving mobility.*
• Patented formula with synergistic ingredients designed to rebuild joint tissue and build type II collagen for quicker relief.*
• Soluble, solvent-free OPC flavanols for collagen formation reinforces joint health.*
• Cellular detoxifier and cartilage repair mineral, Molybdenum, also helps repair by clearing the body of sulfitic and related toxic metabolites that interfere with repair and contribute to pain and fatigue.2*
• Better results are due to purer ingredients and lack of contaminants, such as fillers, binders, or excipients that interfere with its uptake and action in the body.*

RESEARCH SHOWS JOINT REPAIR

Glucosamine sulfate actually reduces osteoarthritis of the knee according to a randomized, placebo-controlled Belgian study appearing in Lancet, January 2001. The 212 study participants, all diagnosed with osteoarthritis, receiving either 1,500 mg. of glucosamine sulfate a day or placebo, were scanned at the beginning of the trial and again at one and three years.* After three years, both osteoarthritis and related symptoms became worse in the placebo group. No progression of osteoarthritis was found after treatment in the glucosamine sulfate group and patients experienced improvement in their symptoms. Researchers concluded that glucosamine sulfate is useful as a long-term disease-modifying agent in osteoarthritis. 3*

Important to note is a comment by Dr. Jean-Yves Reginster of the University of Liege that study findings cannot be extrapolated to other over the-counter products where the amount of active glucosamine is unknown.*

Glucosamine sulfate also outperformed NSAIDS in studies comparing their impact on joint function. Head-to-head against Ibuprofen, after two weeks of treatment, GS not only showed more improvement of symptoms but also was significantly better tolerated.4*

REFERENCES

1. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta analysis. JAMA 2000 Mar 15;283(11):1469-75.
2. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002 Oct 14;162(18):2113-23.
3. Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee Osteoarthritis. Arzneimittelforschung. 1998;48:469- 474.
4. Reginster Jy, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on Osteoarthritis progression: a randomized placebocontrolled clinical trial. Lancet. 2001;27:251-6.